ContiBio & CoBioTech
Continuous bioprocessing of microbial co-cultures: directing population by nutrient pulsing based on single cell data
The ContiBio project aims to contribute towards the control of synthetic co-cultures in continuous bioreactors by assembling a modular computational framework to address phenotypic and genetic instabilities arising at a single-cell level. This project will provide new technologies enabling the control and stability of co-cultures in continuous cultivation devices by addressing the issues related to phenotypic and genetic diversification found in industrial bioprocesses.
Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages
J. Andres Martinez, Matheo Delvenne, Lucas Henrion, Fabian Moreno, Samuel Telek, Christian Dusny, Frank Delvigne. Published: October 31, 2022. https://doi.org/10.1371/journal.pcbi.1010674. PLOS Computational Biology: https://dx.plos.org/10.1371/journal.pcbi.1010674
The kick-off meeting was held on Monday, June 21st, 2021. In was hosted online by Prof. Delvigne @UniversiteLiege, Dr. Christian Dusty @UFZ_de, B.Eng. Delphine Soyeurt @PuratosGroup, and their research teams. We took the first steps towards ContiBio project development and success.
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